Bioactive peptide natural products are interesting leads for the development of pharmaceuticals as they (1) cover a huge chemical space due to their modular structure and (2) are, by their sheer size, able to cover a sufficient surface area on a protein to efficiently interfere with protein-protein interactions. In addition, these peptides often carry modifications of their amino acid side chains or their backbone that improve their pharmacokinetics e.g. provide passive membrane permeability to make them orally available and/or resistance to proteases to increase their retention time in the body...